Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL

The tension-driven gating transition in the large mechanosensitive channel MscL proceeds through detectable states of intermediate conductance. Gain-of-function (GOF) mutants with polar or charged substitutions in the main hydrophobic gate display altered patterns of subconducting states, providing...

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Detalles Bibliográficos
Autores principales: Anishkin, Andriy, Chiang, Chien-Sung, Sukharev, Sergei
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217497/
https://www.ncbi.nlm.nih.gov/pubmed/15684093
http://dx.doi.org/10.1085/jgp.200409118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217497/
https://www.ncbi.nlm.nih.gov/pubmed/15684093
http://dx.doi.org/10.1085/jgp.200409118

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