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Mechanism of the Voltage Sensitivity of IRK1 Inward-rectifier K(+) Channel Block by the Polyamine Spermine
IRK1 (Kir2.1) inward-rectifier K(+) channels exhibit exceedingly steep rectification, which reflects strong voltage dependence of channel block by intracellular cations such as the polyamine spermine. On the basis of studies of IRK1 block by various amine blockers, it was proposed that the observed...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2005
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2217510/ https://www.ncbi.nlm.nih.gov/pubmed/15795311 http://dx.doi.org/10.1085/jgp.200409242 |