Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila

Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia-Lopez, Amparo, Monferrer, Lidon, Garcia-Alcover, Irma, Vicente-Crespo, Marta, Alvarez-Abril, M. Carmen, Artero, Ruben D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220037/
https://www.ncbi.nlm.nih.gov/pubmed/18270582
http://dx.doi.org/10.1371/journal.pone.0001595

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220037/
https://www.ncbi.nlm.nih.gov/pubmed/18270582
http://dx.doi.org/10.1371/journal.pone.0001595

Ejemplares similares