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Genetic and Chemical Modifiers of a CUG Toxicity Model in Drosophila

Non-coding CUG repeat expansions interfere with the activity of human Muscleblind-like (MBNL) proteins contributing to myotonic dystrophy 1 (DM1). To understand this toxic RNA gain-of-function mechanism we developed a Drosophila model expressing 60 pure and 480 interrupted CUG repeats in the context...

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Detalles Bibliográficos
Autores principales:	Garcia-Lopez, Amparo, Monferrer, Lidon, Garcia-Alcover, Irma, Vicente-Crespo, Marta, Alvarez-Abril, M. Carmen, Artero, Ruben D.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2008
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220037/ https://www.ncbi.nlm.nih.gov/pubmed/18270582 http://dx.doi.org/10.1371/journal.pone.0001595

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