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Analysis of the Human Kinome Using Methods Including Fold Recognition Reveals Two Novel Kinases

BACKGROUND: Protein sequence similarity is a commonly used criterion for inferring the unknown function of a protein from a protein of known function. However, proteins can diverge significantly over time such that sequence similarity is difficult, if not impossible, to find. In some cases, a struct...

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Detalles Bibliográficos
Autores principales: Briedis, Kristine M., Starr, Ayelet, Bourne, Philip E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223070/
https://www.ncbi.nlm.nih.gov/pubmed/18270584
http://dx.doi.org/10.1371/journal.pone.0001597