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Simultaneous Binding of Basic Peptides at Intracellular Sites on a Large Conductance Ca(2+)-activated K(+) Channel : Equilibrium and Kinetic Basis of Negatively Coupled Ligand Interactions

The homologous Kunitz inhibitor proteins, bovine pancreatic trypsin inhibitor (BPTI) and dendrotoxin I (DTX-I), interact with large conductance Ca(2+)-activated K(+) channels (maxi-K(Ca)) by binding to an intracellular site outside of the pore to produce discrete substate events. In contrast, certai...

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Detalles Bibliográficos
Autores principales: Favre, Isabelle, Moczydlowski, Edward
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2223364/
https://www.ncbi.nlm.nih.gov/pubmed/9925826