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Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae

BACKGROUND: The IgA1 protease of Streptococcus pneumoniae is a proteolytic enzyme that specifically cleaves the hinge regions of human IgA1, which dominates most mucosal surfaces and is the major IgA isotype in serum. This protease is expressed in all of the known pneumococcal strains and plays a ma...

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Detalles Bibliográficos
Autores principales: De Paolis, Francesca, Beghetto, Elisa, Spadoni, Andrea, Montagnani, Francesca, Felici, Franco, Oggioni, Marco R, Gargano, Nicola
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225412/
https://www.ncbi.nlm.nih.gov/pubmed/18088426
http://dx.doi.org/10.1186/1471-2180-7-113