5-Ethynyluracil (GW776): effects on the formation of the toxic catabolites of 5-fluorouracil, fluoroacetate and fluorohydroxypropionic acid in the isolated perfused rat liver model.

We studied the effects of 5-ethynyluracil (GW776), a potent inactivator of dihydropyrimidine dehydrogenase, on the metabolism of 5-fluorouracil (5-FU), in particular with respect to formation of the toxic compounds fluoroacetate (FAC) and 2-fluoro-3-hydroxypropionic acid (FHPA), using fluorine-19 nu...

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Detalles Bibliográficos
Autores principales: Arellano, M., Malet-Martino, M., Martino, R., Spector, T.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228116/
https://www.ncbi.nlm.nih.gov/pubmed/9365165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228116/
https://www.ncbi.nlm.nih.gov/pubmed/9365165

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