Cargando…

Crystal structure of Leishmania tarentolae hypoxanthine-guanine phosphoribosyltransferase

BACKGROUND: Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (EC 2.4.2.8) is a central enzyme in the purine recycling pathway. Parasitic protozoa of the order Kinetoplastida cannot synthesize purines de novo and use the salvage pathway to synthesize purine bases, making this an attractive targ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Monzani, Paulo S, Trapani, Stefano, Thiemann, Otavio H, Oliva, Glaucius
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228302/ https://www.ncbi.nlm.nih.gov/pubmed/17894860 http://dx.doi.org/10.1186/1472-6807-7-59

Ejemplares similares

Crystal structures and inhibition of Trypanosoma brucei hypoxanthine–guanine phosphoribosyltransferase
por: Terán, David, et al.
Publicado: (2016)

Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases
por: Glockzin, Kayla, et al.
Publicado: (2022)

Novel Hypoxanthine Guanine Phosphoribosyltransferase Gene Mutations in Saudi Arabian Hyperuricemia Patients
por: Alanazi, Mohammed, et al.
Publicado: (2014)

Molecular analysis of hypoxanthine guanine phosphoribosyltransferase (HPRT) gene in five Korean families with Lesch-Nyhan syndrome.
por: Kim, K. J., et al.
Publicado: (1997)

Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors
por: Glockzin, Kayla, et al.
Publicado: (2023)

Evaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt’s B cell lymphoma
por: Townsend, Michelle H., et al.
Publicado: (2020)

Evaluating Iso-Mukaadial Acetate and Ursolic Acid Acetate as Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase Inhibitors
por: Opoku, Francis, et al.
Publicado: (2019)

The Housekeeping Gene Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Regulates Multiple Developmental and Metabolic Pathways of Murine Embryonic Stem Cell Neuronal Differentiation
por: Kang, Tae Hyuk, et al.
Publicado: (2013)

Non-small-cell lung cancer cell lines A549 and NCI-H460 express hypoxanthine guanine phosphoribosyltransferase on the plasma membrane
por: Townsend, Michelle H, et al.
Publicado: (2017)

Hypoxanthine-Guanine Phosphoribosyltransferase/adenylate Kinase From Zobellia galactanivorans: A Bifunctional Catalyst for the Synthesis of Nucleoside-5′-Mono-, Di- and Triphosphates
por: Acosta, Javier, et al.
Publicado: (2020)

Potential molecular link between the β-amyloid precursor protein (APP) and hypoxanthine-guanine phosphoribosyltransferase (HGprt) enzyme in Lesch-Nyhan disease and cancer
por: Nguyen, Khue Vu
Publicado: (2021)

Characterization of in vivo somatic mutations at the hypoxanthine phosphoribosyltransferase gene of a human control population.
por: Burkhart-Schultz, K, et al.
Publicado: (1993)

ACRIFLAVIN RESISTANCE IN THE HEMOFLAGELLATE, LEISHMANIA TARENTOLAE
por: Strauss, Phyllis R.
Publicado: (1972)

Hypoxanthine guanine phosphoribosyltransferase 1, a target of miR-125b-5p, promotes cell proliferation and invasion in head and neck squamous cell carcinoma
por: Yuan, Li, et al.
Publicado: (2023)

Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome
por: Torres, Rosa J, et al.
Publicado: (2007)

Red Blood Cells from Individuals with Lesch–Nyhan Syndrome: Multi-Omics Insights into a Novel S162N Mutation Causing Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency
por: Reisz, Julie A., et al.
Publicado: (2023)

Hypoxanthine-guanine phosphoribosyltransferase and inosine 5′-monophosphate dehydrogenase activities in three mammalian species: aquatic (Mirounga angustirostris), semi-aquatic (Lontra longicaudis annectens) and terrestrial (Sus scrofa)
por: Barjau Pérez-Milicua, Myrna, et al.
Publicado: (2015)

Decreased glutamate transport in acivicin resistant Leishmania tarentolae
por: Roy, Gaétan, et al.
Publicado: (2021)

In Vivo Structure-Function Analysis and Redox Interactomes of Leishmania tarentolae Erv
por: Turra, Gino L., et al.
Publicado: (2021)

Hypoxanthine guanine phosphoribosyl transferases SmHGPRTases functional roles in Schistosoma mansoni
por: Batista, Izabella Cristina Andrade, et al.
Publicado: (2022)

Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy
por: Iatta, Roberta, et al.
Publicado: (2021)

Leishmania (Sauroleishmania) tarentolae isolation and sympatric occurrence with Leishmania (Leishmania) infantum in geckoes, dogs and sand flies
por: Mendoza-Roldan, Jairo Alfonso, et al.
Publicado: (2022)

Leishmania tarentolae: A new frontier in the epidemiology and control of the leishmaniases
por: Mendoza‐Roldan, Jairo Alfonso, et al.
Publicado: (2022)

Proteins and lipids of glycosomal membranes from Leishmania tarentolae and Trypanosoma brucei
por: Colasante, Claudia, et al.
Publicado: (2013)

No Need for Labels: The Autofluorescence of Leishmania tarentolae Mitochondria and the Necessity of Negative Controls
por: Eckers, Elisabeth, et al.
Publicado: (2012)

Generation of hypoxanthine phosphoribosyltransferase gene knockout rabbits by homologous recombination and gene trapping through somatic cell nuclear transfer
por: Yin, Mingru, et al.
Publicado: (2015)

Crystal structure of human nicotinic acid phosphoribosyltransferase
por: Marletta, Ada Serena, et al.
Publicado: (2015)

Assessment of the diagnostic performance of serological tests in areas where Leishmania infantum and Leishmania tarentolae occur in sympatry
por: Iatta, Roberta, et al.
Publicado: (2023)

Development of Various Leishmania (Sauroleishmania) tarentolae Strains in Three Phlebotomus Species
por: Ticha, Lucie, et al.
Publicado: (2021)

Non-invasive visualisation and identification of fluorescent Leishmania tarentolae in infected sand flies
por: Diaz-Albiter, Hector M., et al.
Publicado: (2018)

Leishmania tarentolae novel responses to Bi(3+)-doped strontium aluminum oxyfluorides
por: Apuzzo, C. Fiore, et al.
Publicado: (2021)

Small ncRNA transcriptome analysis from kinetoplast mitochondria of Leishmania tarentolae
por: Madej, Monika J., et al.
Publicado: (2007)

Secretory signal peptide modification for optimized antibody-fragment expression-secretion in Leishmania tarentolae
por: Klatt, Stephan, et al.
Publicado: (2012)

Enhancement of Expression Level of Modified t-PA (TNKase) in Leishmania tarentolae by Induction System
por: Yazdi, Mohammad Mehdi Attarpour, et al.
Publicado: (2019)

Synthesis of Polycyclic Ether-Benzopyrans and In Vitro Inhibitory Activity against Leishmania tarentolae
por: Singh, Sarita, et al.
Publicado: (2020)

Isolation, characterization, and functional study of extracellular vesicles derived from Leishmania tarentolae
por: Shokouhy, Mehrdad, et al.
Publicado: (2022)

Studies of the Effectiveness of Bisphosphonate and Vanadium-Bisphosphonate Compounds In Vitro against Axenic Leishmania tarentolae
por: Christensen, Amy T., et al.
Publicado: (2016)

Detection of Leishmania tarentolae in lizards, sand flies and dogs in southern Italy, where Leishmania infantum is endemic: hindrances and opportunities
por: Mendoza-Roldan, Jairo Alfonso, et al.
Publicado: (2021)

Differences in Charge Distribution in Leishmania tarentolae Leishmanolysin Result in a Reduced Enzymatic Activity
por: Ennes-Vidal, Vítor, et al.
Publicado: (2022)

Human T cell recognition of the blood stage antigen Plasmodium hypoxanthine guanine xanthine phosphoribosyl transferase (HGXPRT) in acute malaria
por: Woodberry, Tonia, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_pu5dhfs3q7lje11grkqd7u3k2b