High CD21 expression inhibits internalization of anti-CD19 antibodies and cytotoxicity of an anti-CD19-drug conjugate

CD19 and CD21 (CR2) are co-receptors found on B-cells and various B-cell lymphomas, including non-Hodgkin lymphoma. To evaluate their suitability as targets for therapy of such lymphomas using internalization-dependent antibody-drug conjugates [such as antibody-4-(N-maleimidomethyl)cyclohexane-1-car...

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Detalles Bibliográficos
Autores principales: Ingle, Gladys S, Chan, Pamela, Elliott, J Michael, Chang, Wesley S, Koeppen, Hartmut, Stephan, Jean-Philippe, Scales, Suzie J
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228374/
https://www.ncbi.nlm.nih.gov/pubmed/17991300
http://dx.doi.org/10.1111/j.1365-2141.2007.06883.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228374/
https://www.ncbi.nlm.nih.gov/pubmed/17991300
http://dx.doi.org/10.1111/j.1365-2141.2007.06883.x

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