Multi-Ion Mechanism for Ion Permeation and Block in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

The mechanism of Cl(−) ion permeation through single cystic fibrosis transmembrane conductance regulator (CFTR) channels was studied using the channel-blocking ion gluconate. High concentrations of intracellular gluconate ions cause a rapid, voltage-dependent block of CFTR Cl(−) channels by binding...

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Detalles Bibliográficos
Autores principales: Linsdell, Paul, Tabcharani, Joseph A., Hanrahan, John W.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229374/
https://www.ncbi.nlm.nih.gov/pubmed/9379169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229374/
https://www.ncbi.nlm.nih.gov/pubmed/9379169

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