Cargando…

Multi-Ion Mechanism for Ion Permeation and Block in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel

The mechanism of Cl(−) ion permeation through single cystic fibrosis transmembrane conductance regulator (CFTR) channels was studied using the channel-blocking ion gluconate. High concentrations of intracellular gluconate ions cause a rapid, voltage-dependent block of CFTR Cl(−) channels by binding...

Descripción completa

Detalles Bibliográficos
Autores principales:	Linsdell, Paul, Tabcharani, Joseph A., Hanrahan, John W.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229374/ https://www.ncbi.nlm.nih.gov/pubmed/9379169

Ejemplares similares

Halide Permeation in Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels
por: Tabcharani, Joseph A., et al.
Publicado: (1997)

Adenosine Triphosphate–dependent Asymmetry of Anion Permeation in the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
por: Linsdell, Paul, et al.
Publicado: (1998)

Permeability of Wild-Type and Mutant Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels to Polyatomic Anions
por: Linsdell, Paul, et al.
Publicado: (1997)

Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore
por: Wang, Wuyang, et al.
Publicado: (2011)

Cystic fibrosis transmembrane conductance regulator (CFTR): Making an ion channel out of an active transporter structure
por: Linsdell, Paul
Publicado: (2018)

Role of the Juxtamembrane Region of Cytoplasmic Loop 3 in the Gating and Conductance of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel
por: El Hiani, Yassine, et al.
Publicado: (2012)

Molecular dynamics study of Cl(−) permeation through cystic fibrosis transmembrane conductance regulator (CFTR)
por: Zeng, Zhi Wei, et al.
Publicado: (2023)

The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor
por: Broadbent, Steven D., et al.
Publicado: (2014)

A multi-ion permeation mechanism in neuronal background chloride channels
Publicado: (1994)

Mechanism of Ion Permeation in Skeletal Muscle Chloride Channels
por: Fahlke, Christoph, et al.
Publicado: (1997)

Changes in the R‐region interactions depend on phosphorylation and contribute to PKA and PKC regulation of the cystic fibrosis transmembrane conductance regulator chloride channel
por: Poroca, Diogo R., et al.
Publicado: (2019)

Locating the Anion-selectivity Filter of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel
por: Cheung, Min, et al.
Publicado: (1997)

Commentary Cystic Fibrosis Transmembrane Conductance Regulator : Permeant Ions Find the Pore
por: Dawson, David C., et al.
Publicado: (1997)

Effect of ATP-sensitive K+ channel regulators on cystic fibrosis transmembrane conductance regulator chloride currents
Publicado: (1992)

Dual Activity of Aminoarylthiazoles on the Trafficking and Gating Defects of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Caused by Cystic Fibrosis Mutations
por: Pedemonte, Nicoletta, et al.
Publicado: (2011)

Ion permeation in potassium ion channels
por: Coates, Leighton
Publicado: (2020)

Ion Conduction Mechanisms in Potassium Channels Revealed by Permeation Cycles
por: Lam, Chun Kei, et al.
Publicado: (2023)

Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation
por: Bai, Yonghong, et al.
Publicado: (2010)

An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions
Publicado: (1985)

Voltage-dependent block of the cystic fibrosis transmembrane conductance regulator Cl- channel by two closely related arylaminobenzoates
Publicado: (1993)

Ion permeation controlled by hydrophobic residues and proton binding in the proton-activated chloride channel
por: Cai, Ruiqi, et al.
Publicado: (2021)

Cystic Fibrosis Transmembrane Conductance Regulator–associated ATP Release Is Controlled by a Chloride Sensor
por: Jiang, Qinshi, et al.
Publicado: (1998)

Voltage-dependent Gating of the Cystic Fibrosis Transmembrane Conductance Regulator Cl(−) Channel
por: Cai, Zhiwei, et al.
Publicado: (2003)

Characterization of Defects in Ion Transport and Tissue Development in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Knockout Rats
por: Tuggle, Katherine L., et al.
Publicado: (2014)

Glycosylation and the cystic fibrosis transmembrane conductance regulator
por: Scanlin, Thomas F, et al.
Publicado: (2001)

Where Is the Cystic Fibrosis Transmembrane Conductance Regulator?
por: Barbry, Pascal, et al.
Publicado: (2021)

Determinants of Anion Permeation in the Second Transmembrane Domain of the Mouse Bestrophin-2 Chloride Channel
por: Qu, Zhiqiang, et al.
Publicado: (2004)

Mutation-induced Blocker Permeability and Multiion Block of the CFTR Chloride Channel Pore
por: Gong, Xiandi, et al.
Publicado: (2003)

Block of neuronal chloride channels by tetraethylammonium ion derivatives
Publicado: (1995)

Gating of Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channels by Adenosine Triphosphate Hydrolysis : Quantitative Analysis of a Cyclic Gating Scheme
por: Zeltwanger, Shawn, et al.
Publicado: (1999)

Batrachotoxin-modified sodium channels in planar lipid bilayers. Ion permeation and block
Publicado: (1987)

Knocking on channel's door. The permeating chloride ion acts as the gating charge in ClC-0
Publicado: (1996)

Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives
por: Schmidt, Béla Z, et al.
Publicado: (2016)

The Extrapulmonary Effects of Cystic Fibrosis Transmembrane Conductance Regulator Modulators in Cystic Fibrosis
por: Sergeev, Valentine, et al.
Publicado: (2020)

A Synthetic Chloride Channel Restores Chloride Conductance in Human Cystic Fibrosis Epithelial Cells
por: Shen, Bing, et al.
Publicado: (2012)

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS
por: Corradi, Valentina, et al.
Publicado: (2015)

Positive Charges at the Intracellular Mouth of the Pore Regulate Anion Conduction in the CFTR Chloride Channel
por: Aubin, Chantal N. St., et al.
Publicado: (2006)

Temperature dependence of ion permeation at the endplate channel
Publicado: (1983)

Acquired cystic fibrosis transmembrane conductance regulator dysfunction
por: Banks, Catherine, et al.
Publicado: (2018)

Targeted Activation of Cystic Fibrosis Transmembrane Conductance Regulator
por: Villamizar, Olga, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_v3pfdamjo58t462v8jfbc3tond