On the Structural Basis for Size-selective Permeation of Organic Cations through the Voltage-gated Sodium Channel : Effect of Alanine Mutations at the DEKA Locus on Selectivity, Inhibition by Ca(2+) and H(+), and Molecular Sieving

Recent evidence indicates that ionic selectivity in voltage-gated Na(+) channels is mediated by a small number of residues in P-region segments that link transmembrane elements S5 and S6 in each of four homologous domains denoted I, II, III, and IV. Important determinants for this function appear to...

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Detalles Bibliográficos
Autores principales: Sun, Ye-Ming, Favre, Isabelle, Schild, Laurent, Moczydlowski, Edward
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1997
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229404/
https://www.ncbi.nlm.nih.gov/pubmed/9382897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229404/
https://www.ncbi.nlm.nih.gov/pubmed/9382897

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