Interactions between Multiple Phosphorylation Sites in the Inactivation Particle of a K(+) Channel : Insights into the Molecular Mechanism of Protein Kinase C Action

Protein kinase C inhibits inactivation gating of Kv3.4 K(+) channels, and at least two NH(2)-terminal serines (S15 and S21) appeared involved in this interaction (Covarrubias et al. 1994. Neuron. 13:1403–1412). Here we have investigated the molecular mechanism of this regulatory process. Site-direct...

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Detalles Bibliográficos
Autores principales: Beck, Edward J., Sorensen, Roger G., Slater, Simon J., Covarrubias, Manuel
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1998
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229409/
https://www.ncbi.nlm.nih.gov/pubmed/9649584

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229409/
https://www.ncbi.nlm.nih.gov/pubmed/9649584

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