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Extracellular Zinc Ion Inhibits ClC-0 Chloride Channels by Facilitating Slow Gating
Extracellular Zn(2+) was found to reversibly inhibit the ClC-0 Cl(−) channel. The apparent on and off rates of the inhibition were highly temperature sensitive, suggesting an effect of Zn(2+) on the slow gating (or inactivation) of ClC-0. In the absence of Zn(2+), the rate of the slow-gating relaxat...
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
1998
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229451/ https://www.ncbi.nlm.nih.gov/pubmed/9834141 |