Localization of the K(+) Lock-in and the Ba(2+) Binding Sites in a Voltage-Gated Calcium-Modulated Channel: Implications for Survival of K(+) Permeability

Using Ba(2+) as a probe, we performed a detailed characterization of an external K(+) binding site located in the pore of a large conductance Ca(2+)-activated K(+) (BK(Ca)) channel from skeletal muscle incorporated into planar lipid bilayers. Internal Ba(2+) blocks BK(Ca) channels and decreasing ext...

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Detalles Bibliográficos
Autores principales: Vergara, Cecilia, Alvarez, Osvaldo, Latorre, Ramon
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229454/
https://www.ncbi.nlm.nih.gov/pubmed/10469727

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