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Molecular Coupling of S4 to a K(+) Channel's Slow Inactivation Gate

The mechanism by which physiological signals regulate the conformation of molecular gates that open and close ion channels is poorly understood. Voltage clamp fluorometry was used to ask how the voltage-sensing S4 transmembrane domain is coupled to the slow inactivation gate in the pore domain of th...

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Detalles Bibliográficos
Autores principales: Loots, Eli, Isacoff, Ehud Y.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229480/
https://www.ncbi.nlm.nih.gov/pubmed/11055991