Neutralization of Gating Charges in Domain II of the Sodium Channel α Subunit Enhances Voltage-Sensor Trapping by a β-Scorpion Toxin

β-Scorpion toxins shift the voltage dependence of activation of sodium channels to more negative membrane potentials, but only after a strong depolarizing prepulse to fully activate the channels. Their receptor site includes the S3–S4 loop at the extracellular end of the S4 voltage sensor in domain...

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Detalles Bibliográficos
Autores principales: Cestèle, Sandrine, Scheuer, Todd, Mantegazza, Massimo, Rochat, Hervé, Catterall, William A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229501/
https://www.ncbi.nlm.nih.gov/pubmed/11524459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229501/
https://www.ncbi.nlm.nih.gov/pubmed/11524459

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