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External TEA Block of Shaker K(+) Channels Is Coupled to the Movement of K(+) Ions within the Selectivity Filter

Recent molecular dynamic simulations and electrostatic calculations suggested that the external TEA binding site in K(+) channels is outside the membrane electric field. However, it has been known for some time that external TEA block of Shaker K(+) channels is voltage dependent. To reconcile these...

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Detalles Bibliográficos
Autores principales: Thompson, Jill, Begenisich, Ted
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229542/
https://www.ncbi.nlm.nih.gov/pubmed/12885878
http://dx.doi.org/10.1085/jgp.200308848