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Probing an Open CFTR Pore with Organic Anion Blockers
The cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that conducts Cl(−) current. We explored the CFTR pore by studying voltage-dependent blockade of the channel by two organic anions: glibenclamide and isethionate. To simplify the kinetic analysis, a CFTR mutant, K1250A-...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229557/ https://www.ncbi.nlm.nih.gov/pubmed/12407077 http://dx.doi.org/10.1085/jgp.20028685 |