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Ligand-induced Closure of Inward Rectifier Kir6.2 Channels Traps Spermine in the Pore
Small organic amines block open voltage-gated K(+) channels and can be trapped by subsequent closure. Such studies provide strong evidence for voltage gating occurring at the intracellular end of the channel. We engineered the necessary properties (long block times with unblock kinetics comparable t...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229588/ https://www.ncbi.nlm.nih.gov/pubmed/14638936 http://dx.doi.org/10.1085/jgp.200308953 |