Mutation-induced Blocker Permeability and Multiion Block of the CFTR Chloride Channel Pore

Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is blocked by a broad range of anions that bind tightly within the pore. Here we show that the divalent anion Pt(NO(2))(4) (2−) acts as an impermeant voltage-dependent blocker of the CFTR pore wh...

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Detalles Bibliográficos
Autores principales: Gong, Xiandi, Linsdell, Paul
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229596/
https://www.ncbi.nlm.nih.gov/pubmed/14610019
http://dx.doi.org/10.1085/jgp.200308889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229596/
https://www.ncbi.nlm.nih.gov/pubmed/14610019
http://dx.doi.org/10.1085/jgp.200308889

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