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Mutation-induced Blocker Permeability and Multiion Block of the CFTR Chloride Channel Pore
Chloride permeation through the cystic fibrosis transmembrane conductance regulator (CFTR) Cl(−) channel is blocked by a broad range of anions that bind tightly within the pore. Here we show that the divalent anion Pt(NO(2))(4) (2−) acts as an impermeant voltage-dependent blocker of the CFTR pore wh...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229596/ https://www.ncbi.nlm.nih.gov/pubmed/14610019 http://dx.doi.org/10.1085/jgp.200308889 |