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Block of Tetrodotoxin-resistant Na(+) Channel Pore by Multivalent Cations: Gating Modification and Na(+) Flow Dependence
Tetrodotoxin-resistant (TTX-R) Na(+) channels are much less susceptible to external TTX but more susceptible to external Cd(2+) block than tetrodotoxin-sensitive (TTX-S) Na(+) channels. Both TTX and Cd(2+) seem to block the channel near the “DEKA” ring, which is probably part of a multi-ion single-f...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229605/ https://www.ncbi.nlm.nih.gov/pubmed/15226363 http://dx.doi.org/10.1085/jgp.200409054 |