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Voltage and Ca(2+) Activation of Single Large-Conductance Ca(2+)-Activated K(+) Channels Described by a Two-Tiered Allosteric Gating Mechanism
The voltage- and Ca(2+)-dependent gating mechanism of large-conductance Ca(2+)-activated K(+) (BK) channels from cultured rat skeletal muscle was studied using single-channel analysis. Channel open probability (P (o)) increased with depolarization, as determined by limiting slope measurements (11 mV...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2000
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229615/ https://www.ncbi.nlm.nih.gov/pubmed/10871641 |