Regulation of K(+) Flow by a Ring of Negative Charges in the Outer Pore of BK(Ca) Channels. Part II: Neutralization of Aspartate 292 Reduces Long Channel Openings and Gating Current Slow Component

Neutralization of the aspartate near the selectivity filter in the GYGD pore sequence (D292N) of the voltage- and Ca(2+)-activated K(+) channel (MaxiK, BKCa) does not prevent conduction like the corresponding mutation in Shaker channel, but profoundly affects major biophysical properties of the chan...

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Detalles Bibliográficos
Autores principales: Haug, Trude, Olcese, Riccardo, Toro, Ligia, Stefani, Enrico
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229619/
https://www.ncbi.nlm.nih.gov/pubmed/15277579
http://dx.doi.org/10.1085/jgp.200308950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229619/
https://www.ncbi.nlm.nih.gov/pubmed/15277579
http://dx.doi.org/10.1085/jgp.200308950

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