Discovery of Glycine Hydrazide Pore-occluding CFTR Inhibitors: Mechanism, Structure–Activity Analysis, and In Vivo Efficacy

The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a cAMP-regulated epithelial Cl(−) channel that, when defective, causes cystic fibrosis. Screening of a collection of 100,000 diverse small molecules revealed four novel chemical classes of CFTR inhibitors with K(i) < 10 μM,...

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Detalles Bibliográficos
Autores principales: Muanprasat, Chatchai, Sonawane, N.D., Salinas, Danieli, Taddei, Alessandro, Galietta, Luis J.V., Verkman, A.S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229623/
https://www.ncbi.nlm.nih.gov/pubmed/15277574
http://dx.doi.org/10.1085/jgp.200409059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229623/
https://www.ncbi.nlm.nih.gov/pubmed/15277574
http://dx.doi.org/10.1085/jgp.200409059

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