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Regulation of K(+) Flow by a Ring of Negative Charges in the Outer Pore of BK(Ca) Channels. Part I: Aspartate 292 modulates K(+) Conduction by External Surface Charge Effect
The pore region of the majority of K(+) channels contains the highly conserved GYGD sequence, known as the K(+) channel signature sequence, where the GYG is critical for K(+) selectivity (Heginbotham, L., T. Abramson, and R. MacKinnon. 1992. Science. 258:1152–1155). Exchanging the aspartate residue...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229624/ https://www.ncbi.nlm.nih.gov/pubmed/15277578 http://dx.doi.org/10.1085/jgp.200308949 |