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Regulation of K(+) Flow by a Ring of Negative Charges in the Outer Pore of BK(Ca) Channels. Part I: Aspartate 292 modulates K(+) Conduction by External Surface Charge Effect

The pore region of the majority of K(+) channels contains the highly conserved GYGD sequence, known as the K(+) channel signature sequence, where the GYG is critical for K(+) selectivity (Heginbotham, L., T. Abramson, and R. MacKinnon. 1992. Science. 258:1152–1155). Exchanging the aspartate residue...

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Detalles Bibliográficos
Autores principales:	Haug, Trude, Sigg, Daniel, Ciani, Sergio, Toro, Ligia, Stefani, Enrico, Olcese, Riccardo
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2004
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229624/ https://www.ncbi.nlm.nih.gov/pubmed/15277578 http://dx.doi.org/10.1085/jgp.200308949

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