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Isolation of a Single Carboxyl-Carboxylate Proton Binding Site in the Pore of a Cyclic Nucleotide–Gated Channel

The pore of the catfish olfactory cyclic nucleotide–gated (CNG) channel contains four conserved glutamate residues, one from each subunit, that form a high-affinity binding site for extracellular divalent cations. Previous work showed that these residues form two independent and equivalent high-pK(a...

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Detalles Bibliográficos
Autores principales: Morrill, James A., MacKinnon, Roderick
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229637/
https://www.ncbi.nlm.nih.gov/pubmed/10398693