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Calcium Wave Propagation in Pancreatic Acinar Cells: Functional Interaction of Inositol 1,4,5-Trisphosphate Receptors, Ryanodine Receptors, and Mitochondria

In pancreatic acinar cells, inositol 1,4,5-trisphosphate (InsP(3))–dependent cytosolic calcium ([Ca(2+)](i)) increases resulting from agonist stimulation are initiated in an apical “trigger zone,” where the vast majority of InsP(3) receptors (InsP(3)R) are localized. At threshold stimulation, [Ca(2+...

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Detalles Bibliográficos
Autores principales: Straub, Stephen V., Giovannucci, David R., Yule, David I.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230627/
https://www.ncbi.nlm.nih.gov/pubmed/11004204