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An epigenetic vaccine model active in the prevention and treatment of melanoma

BACKGROUND: Numerous immune genes are epigenetically silenced in tumor cells and agents such as histone deacetylase inhibitors (HDACi), which reverse these effects, could potentially be used to develop therapeutic vaccines. The conversion of cancer cells to antigen presenting cells (APCs) by HDACi t...

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Detalles Bibliográficos
Autores principales: Khan, A Nazmul H, Magner, William J, Tomasi, Thomas B
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2231344/
https://www.ncbi.nlm.nih.gov/pubmed/18070359
http://dx.doi.org/10.1186/1479-5876-5-64