Cargando…

Inactivation of Bk Channels Mediated by the Nh(2) Terminus of the β3b Auxiliary Subunit Involves a Two-Step Mechanism: Possible Separation of Binding and Blockade

A family of auxiliary β subunits coassemble with Slo α subunit to form Ca(2)+-regulated, voltage-activated BK-type K(+) channels. The β subunits play an important role in regulating the functional properties of the resulting channel protein, including apparent Ca(2)+ dependence and inactivation. The...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lingle, Christopher J., Zeng, Xu-Hui, Ding, J.-P., Xia, Xiao-Ming
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2001
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2232400/ https://www.ncbi.nlm.nih.gov/pubmed/11382808

Ejemplares similares

Inactivation of BK Channels by the NH(2) Terminus of the β2 Auxiliary Subunit: An Essential Role of a Terminal Peptide Segment of Three Hydrophobic Residues
por: Xia, Xiao-Ming, et al.
Publicado: (2003)

Gating Properties Conferred on Bk Channels by the β3b Auxiliary Subunit in the Absence of Its Nh(2)- and Cooh Termini
por: Zeng, Xu-Hui, et al.
Publicado: (2001)

Regulation of BK channels by auxiliary γ subunits
por: Zhang, Jiyuan, et al.
Publicado: (2014)

Pharmacological consequences of the coexpression of BK channel α and auxiliary β subunits
por: Torres, Yolima P., et al.
Publicado: (2014)

Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation
por: Guan, Xin, et al.
Publicado: (2017)

N-terminal Inactivation Domains of β Subunits Are Protected from Trypsin Digestion by Binding within the Antechamber of BK Channels
por: Zhang, Zhe, et al.
Publicado: (2009)

Species-specific Differences among KCNMB3 BK β3 Auxiliary Subunits: Some β3 N-terminal Variants May Be Primate-specific Subunits
por: Zeng, Xuhui, et al.
Publicado: (2008)

The single transmembrane segment determines the modulatory function of the BK channel auxiliary γ subunit
por: Li, Qin, et al.
Publicado: (2016)

The NH(2) Terminus of RCK1 Domain Regulates Ca(2+)-dependent BK(Ca) Channel Gating
por: Krishnamoorthy, Gayathri, et al.
Publicado: (2005)

Direct Observation of a Preinactivated, Open State in BK Channels with β2 Subunits
por: Benzinger, G. Richard, et al.
Publicado: (2006)

Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating
por: Gonzalez-Perez, Vivian, et al.
Publicado: (2015)

Stereospecific binding of a disordered peptide segment mediates BK channel inactivation
por: Gonzalez-Perez, Vivian, et al.
Publicado: (2012)

Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary γ subunits
por: Li, Qin, et al.
Publicado: (2015)

Knockout of the BK β2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity
por: Martinez-Espinosa, Pedro L., et al.
Publicado: (2014)

S-Glutathionylation of an Auxiliary Subunit Confers Redox Sensitivity to Kv4 Channel Inactivation
por: Jerng, Henry H., et al.
Publicado: (2014)

The leucine-rich repeat domains of BK channel auxiliary γ subunits regulate their expression, trafficking, and channel-modulation functions
por: Chen, Guanxing, et al.
Publicado: (2022)

Setting the Stage for Molecular Dissection of the Regulatory Components of BK Channels
por: Lingle, Christopher J.
Publicado: (2002)

Mg(2+)-dependent Regulation of BK Channels: Importance of Electrostatics
por: Lingle, Christopher J.
Publicado: (2008)

Two distinct effects of PIP(2) underlie auxiliary subunit-dependent modulation of Slo1 BK channels
por: Tian, Yutao, et al.
Publicado: (2015)

BK channel modulation by positively charged peptides and auxiliary γ subunits mediated by the Ca(2+)-bowl site
por: Chen, Guanxing, et al.
Publicado: (2023)

BK channel inhibition by strong extracellular acidification
por: Zhou, Yu, et al.
Publicado: (2018)

Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism
por: Zhou, Yu, et al.
Publicado: (2014)

BK channel β1 and β4 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice
por: Kreifeldt, Max, et al.
Publicado: (2013)

Glycine(311), a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix
por: Zhou, Yu, et al.
Publicado: (2010)

Closed-channel block of BK potassium channels by bbTBA requires partial activation
por: Tang, Qiong-Yao, et al.
Publicado: (2009)

Oligomerization and maturation of Na,K-ATPase: functional interaction of the cytoplasmic NH2 terminus of the beta subunit with the alpha subunit
Publicado: (1996)

Mechanism of β4 Subunit Modulation of BK Channels
por: Wang, Bin, et al.
Publicado: (2006)

Location of modulatory β subunits in BK potassium channels
por: Liu, Guoxia, et al.
Publicado: (2010)

Trafficking of BK channel subunits controls arterial contractility
por: Leo, M. Dennis, et al.
Publicado: (2017)

Emerging roles for multifunctional ion channel auxiliary subunits in cancer
por: Haworth, Alexander S., et al.
Publicado: (2019)

Distinct domains of the β1-subunit cytosolic N terminus control surface expression and functional properties of large-conductance calcium-activated potassium (BK) channels
por: Chen, Lie, et al.
Publicado: (2017)

Divalent Cation Sensitivity of BK Channel Activation Supports the Existence of Three Distinct Binding Sites
por: Zeng, Xu-Hui, et al.
Publicado: (2005)

Modes of Operation of the BK(Ca) Channel β(2) Subunit
por: Savalli, Nicoletta, et al.
Publicado: (2007)

BK channel inactivation gates daytime excitability in the circadian clock
por: Whitt, Joshua P., et al.
Publicado: (2016)

Measuring the Influence of the BK(Ca) β1 Subunit on Ca(2+) Binding to the BK(Ca) Channel
por: Sweet, Tara-Beth, et al.
Publicado: (2009)

S-Acylation controls functional coupling of BK channel pore-forming α-subunits and β1-subunits
por: Duncan, Peter J., et al.
Publicado: (2019)

Alcohol modulation of BK channel gating depends on β subunit composition
por: Kuntamallappanavar, Guruprasad, et al.
Publicado: (2016)

The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels
por: Campiglio, Marta, et al.
Publicado: (2015)

Voltage‐gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology
por: Dolphin, Annette C.
Publicado: (2016)

Antibodies Against the NH(2)-Terminus of the GluA Subunits Affect the AMPA-Evoked Releasing Activity: The Role of Complement
por: Cisani, Francesca, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_dg6tnjkn4vpodd89sa1c51h6m5