Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.

BACKGROUND: Kynureninase is a key enzyme on the kynurenine pathway of tryptophan metabolism. One of the end products of the pathway is the neurotoxin quinolinic acid which appears to be responsible for neuronal cell death in a number of important neurological diseases. This makes kynureninase a poss...

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Detalles Bibliográficos
Autores principales: Walsh, Harold A, O'Shea, Karen C, Botting, Nigel P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2003
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC223355/
https://www.ncbi.nlm.nih.gov/pubmed/14505498
http://dx.doi.org/10.1186/1471-2091-4-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC223355/
https://www.ncbi.nlm.nih.gov/pubmed/14505498
http://dx.doi.org/10.1186/1471-2091-4-13

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