Pkc-Mediated Stimulation of Amphibian Cftr Depends on a Single Phosphorylation Consensus Site. Insertion of This Site Confers Pkc Sensitivity to Human Cftr

Mutations of the CFTR, a phosphorylation-regulated Cl(−) channel, cause cystic fibrosis. Activation of CFTR by PKA stimulation appears to be mediated by a complex interaction between several consensus phosphorylation sites in the regulatory domain (R domain). None of these sites has a critical role...

Descripción completa

Detalles Bibliográficos
Autores principales: Button, Brian, Reuss, Luis, Altenberg, Guillermo A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233655/
https://www.ncbi.nlm.nih.gov/pubmed/11331356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233655/
https://www.ncbi.nlm.nih.gov/pubmed/11331356

Ejemplares similares