Drosophila brca2 Is Required for Mitotic and Meiotic DNA Repair and Efficient Activation of the Meiotic Recombination Checkpoint

Heterozygous mutations in the tumor suppressor BRCA2 confer a high risk of breast and other cancers in humans. BRCA2 maintains genome stability in part through the regulation of Rad51-dependent homologous recombination. Much about its precise function in the DNA damage responses is, however, not yet...

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Detalles Bibliográficos
Autores principales: Klovstad, Martha, Abdu, Uri, Schüpbach, Trudi
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233675/
https://www.ncbi.nlm.nih.gov/pubmed/18266476
http://dx.doi.org/10.1371/journal.pgen.0040031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233675/
https://www.ncbi.nlm.nih.gov/pubmed/18266476
http://dx.doi.org/10.1371/journal.pgen.0040031

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