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Ion–Ion Interactions at the Selectivity Filter: Evidence from K(+)-Dependent Modulation of Tetraethylammonium Efficacy in Kv2.1 Potassium Channels
In the Kv2.1 potassium channel, binding of K(+) to a high-affinity site associated with the selectivity filter modulates channel sensitivity to external TEA. In channels carrying Na(+) current, K(+) interacts with the TEA modulation site at concentrations ≤30 μM. In this paper, we further characteri...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2000
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233752/ https://www.ncbi.nlm.nih.gov/pubmed/10736316 |