Extracellular Blockade of K(+) Channels by Tea: Results from Molecular Dynamics Simulations of the Kcsa Channel

TEA is a classical blocker of K(+) channels. From mutagenesis studies, it has been shown that external blockade by TEA is strongly dependent upon the presence of aromatic residue at Shaker position 449 which is located near the extracellular entrance to the pore (Heginbotham, L., and R. MacKinnon. 1...

Descripción completa

Detalles Bibliográficos
Autores principales: Crouzy, Serge, Bernèche, Simon, Roux, Benoît
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233828/
https://www.ncbi.nlm.nih.gov/pubmed/11479347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233828/
https://www.ncbi.nlm.nih.gov/pubmed/11479347

Ejemplares similares