Efficient Coupling of Ligand Binding to Channel Opening by the Binding Domain of a Modulatory (β) Subunit of the Olfactory Cyclic Nucleotide-Gated Channel

CNG channels in vivo are heteromers of homologous α and β subunits that each contain a six-transmembrane segment domain and a COOH-terminal cytoplasmic cyclic nucleotide binding domain (BD). In heterologous expression systems, heteromeric αβ channels activate with greater sensitivity to ligand than...

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Detalles Bibliográficos
Autores principales: Young, Edgar C., Sciubba, Daniel M., Siegelbaum, Steven A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2001
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233835/
https://www.ncbi.nlm.nih.gov/pubmed/11696610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233835/
https://www.ncbi.nlm.nih.gov/pubmed/11696610

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