Electrostatic and Steric Contributions to Block of the Skeletal Muscle Sodium Channel by μ-Conotoxin

Pore-blocking toxins are valuable probes of ion channels that underlie electrical signaling. To be effective inhibitors, they must show high affinity and specificity and prevent ion conduction. The 22-residue sea snail peptide, μ-conotoxin GIIIA, blocks the skeletal muscle sodium channel completely....

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Detalles Bibliográficos
Autores principales: Hui, Kwokyin, Lipkind, Gregory, Fozzard, Harry A., French, Robert J.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2002
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233858/
https://www.ncbi.nlm.nih.gov/pubmed/11773237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233858/
https://www.ncbi.nlm.nih.gov/pubmed/11773237

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