Molecular Basis of Inward Rectification: Polyamine Interaction Sites Located by Combined Channel and Ligand Mutagenesis

Polyamines cause inward rectification of (Kir) K(+) channels, but the mechanism is controversial. We employed scanning mutagenesis of Kir6.2, and a structural series of blocking diamines, to combinatorially examine the role of both channel and blocker charges. We find that introduced glutamates at a...

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Detalles Bibliográficos
Autores principales: Kurata, Harley T., Phillips, L. Revell, Rose, Thierry, Loussouarn, Gildas, Herlitze, Stefan, Fritzenschaft, Hariolf, Enkvetchakul, Decha, Nichols, Colin G., Baukrowitz, Thomas
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234007/
https://www.ncbi.nlm.nih.gov/pubmed/15477380
http://dx.doi.org/10.1085/jgp.200409159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234007/
https://www.ncbi.nlm.nih.gov/pubmed/15477380
http://dx.doi.org/10.1085/jgp.200409159

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