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Luminal Ca(2+)–regulated Mg(2+) Inhibition of Skeletal RyRs Reconstituted as Isolated Channels or Coupled Clusters
In resting muscle, cytoplasmic Mg(2+) is a potent inhibitor of Ca(2+) release from the sarcoplasmic reticulum (SR). It is thought to inhibit calcium release channels (RyRs) by binding both to low affinity, low specificity sites (I-sites) and to high affinity Ca(2+) sites (A-sites) thus preventing Ca...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2004
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234024/ https://www.ncbi.nlm.nih.gov/pubmed/15545399 http://dx.doi.org/10.1085/jgp.200409092 |