Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

The role of Th17 cells in type I diabetes (TID) remains largely unknown. Glutamic acid decarboxylase (GAD) sequence 206–220 (designated GAD2) represents a late-stage epitope, but GAD2-specific T cell receptor transgenic T cells producing interferon γ (IFNγ) protect against passive TID. Because IFNγ...

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Detalles Bibliográficos
Autores principales: Jain, Renu, Tartar, Danielle M., Gregg, Randal K., Divekar, Rohit D., Bell, J. Jeremiah, Lee, Hyun-Hee, Yu, Ping, Ellis, Jason S., Hoeman, Christine M., Franklin, Craig L., Zaghouani, Habib
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2008
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234380/
https://www.ncbi.nlm.nih.gov/pubmed/18195074
http://dx.doi.org/10.1084/jem.20071878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234380/
https://www.ncbi.nlm.nih.gov/pubmed/18195074
http://dx.doi.org/10.1084/jem.20071878

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