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Conformational Changes in the Pore of CLC-0
The Torpedo Cl(−) channel, CLC-0, is inhibited by clofibric acid derivatives from the intracellular side. We used the slow gate-deficient mutant CLC-0(C212S) to investigate the mechanism of block by the clofibric acid–derivative p-chlorophenoxy-acetic acid (CPA). CPA blocks open channels with low af...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234480/ https://www.ncbi.nlm.nih.gov/pubmed/12913090 http://dx.doi.org/10.1085/jgp.200308834 |