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Conformational Changes in the Pore of CLC-0

The Torpedo Cl(−) channel, CLC-0, is inhibited by clofibric acid derivatives from the intracellular side. We used the slow gate-deficient mutant CLC-0(C212S) to investigate the mechanism of block by the clofibric acid–derivative p-chlorophenoxy-acetic acid (CPA). CPA blocks open channels with low af...

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Detalles Bibliográficos
Autores principales:	Accardi, Alessio, Pusch, Michael
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234480/ https://www.ncbi.nlm.nih.gov/pubmed/12913090 http://dx.doi.org/10.1085/jgp.200308834

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