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State-dependent Block of Wild-type and Inactivation-deficient Na(+) Channels by Flecainide
The antiarrhythmic agent flecainide appears beneficial for painful congenital myotonia and LQT-3/ΔKPQ syndrome. Both diseases manifest small but persistent late Na(+) currents in skeletal or cardiac myocytes. Flecainide may therefore block late Na(+) currents for its efficacy. To investigate this po...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2003
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234482/ https://www.ncbi.nlm.nih.gov/pubmed/12913091 http://dx.doi.org/10.1085/jgp.200308857 |