Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH(2)-terminal Nucleotide Binding Domain and its Role in Channel Gating

CFTR, the protein defective in cystic fibrosis, functions as a Cl(−) channel regulated by cAMP-dependent protein kinase (PKA). CFTR is also an ATPase, comprising two nucleotide-binding domains (NBDs) thought to bind and hydrolyze ATP. In hydrolyzable nucleoside triphosphates, PKA-phosphorylated CFTR...

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Detalles Bibliográficos
Autores principales: Basso, Claudia, Vergani, Paola, Nairn, Angus C., Gadsby, David C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234483/
https://www.ncbi.nlm.nih.gov/pubmed/12939393
http://dx.doi.org/10.1085/jgp.200308798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234483/
https://www.ncbi.nlm.nih.gov/pubmed/12939393
http://dx.doi.org/10.1085/jgp.200308798

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