Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca(2+)

We tested the long-standing hypothesis that synaptotagmin 1 is the Ca(2+) sensor for fast neurosecretion by analyzing the intracellular Ca(2+) dependence of large dense-core vesicle exocytosis in a mouse strain carrying a mutated synaptotagmin C2A domain. The mutation (R233Q) causes a twofold increa...

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Detalles Bibliográficos
Autores principales: Sørensen, Jakob B., Fernández-Chacón, Rafael, Südhof, Thomas C., Neher, Erwin
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234490/
https://www.ncbi.nlm.nih.gov/pubmed/12939392
http://dx.doi.org/10.1085/jgp.200308855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234490/
https://www.ncbi.nlm.nih.gov/pubmed/12939392
http://dx.doi.org/10.1085/jgp.200308855

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