Cargando…

Examining Synaptotagmin 1 Function in Dense Core Vesicle Exocytosis under Direct Control of Ca(2+)

We tested the long-standing hypothesis that synaptotagmin 1 is the Ca(2+) sensor for fast neurosecretion by analyzing the intracellular Ca(2+) dependence of large dense-core vesicle exocytosis in a mouse strain carrying a mutated synaptotagmin C2A domain. The mutation (R233Q) causes a twofold increa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sørensen, Jakob B., Fernández-Chacón, Rafael, Südhof, Thomas C., Neher, Erwin
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234490/ https://www.ncbi.nlm.nih.gov/pubmed/12939392 http://dx.doi.org/10.1085/jgp.200308855

Ejemplares similares

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca(2+)-dependent priming
por: Tawfik, Bassam, et al.
Publicado: (2021)

Reconstitution of calcium-mediated exocytosis of dense-core vesicles
por: Kreutzberger, Alex J. B., et al.
Publicado: (2017)

MicroRNA exocytosis by large dense-core vesicle fusion
por: Gümürdü, Alican, et al.
Publicado: (2017)

Architecture of the Synaptotagmin-SNARE Machinery for Neuronal Exocytosis
por: Zhou, Qiangjun, et al.
Publicado: (2015)

Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4
por: Bharat, Vinita, et al.
Publicado: (2017)

Postsynaptic Synaptotagmins Mediate AMPA Receptor Exocytosis During LTP
por: Wu, Dick, et al.
Publicado: (2017)

Synaptotagmin 1 directs repetitive release by coupling vesicle exocytosis to the Rab3 cycle
por: Cheng, Yunsheng, et al.
Publicado: (2015)

Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons
por: Subkhangulova, Aygul, et al.
Publicado: (2023)

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis
por: Man, Kwun Nok M, et al.
Publicado: (2015)

Distinct fusion properties of synaptotagmin-1 and synaptotagmin-7 bearing dense core granules
por: Rao, Tejeshwar C., et al.
Publicado: (2014)

Synaptotagmin VII Regulates Ca(2+)-Dependent Exocytosis of Lysosomes in Fibroblasts
por: Martinez, Iñigo, et al.
Publicado: (2000)

Ca(2+) sensor synaptotagmin-1 mediates exocytosis in mammalian photoreceptors
por: Grassmeyer, Justin J, et al.
Publicado: (2019)

Uncoupling the roles of synaptotagmin I as a dual Ca(2+) sensor during endo- and exocytosis of synaptic vesicles
por: Yao, Jun, et al.
Publicado: (2011)

Cycling of Dense Core Vesicles Involved in Somatic Exocytosis of Serotonin by Leech Neurons
por: Trueta, Citlali, et al.
Publicado: (2012)

Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles
por: Chiang, Hsueh-Cheng, et al.
Publicado: (2014)

Dense‐core vesicle biogenesis and exocytosis in neurons lacking chromogranins A and B
por: Dominguez, Natalia, et al.
Publicado: (2017)

High-speed imaging reveals the bimodal nature of dense core vesicle exocytosis
por: Zhang, Pengcheng, et al.
Publicado: (2022)

The Role of Calmodulin vs. Synaptotagmin in Exocytosis
por: Xue, Renhao, et al.
Publicado: (2021)

Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
por: Kobbersmed, Janus RL, et al.
Publicado: (2022)

Synaptotagmin II Negatively Regulates Ca(2+)-triggered Exocytosis of Lysosomes in Mast Cells
por: Baram, Dana, et al.
Publicado: (1999)

Release mode of large and small dense-core vesicles specified by different synaptotagmin isoforms in PC12 cells
por: Zhang, Zhen, et al.
Publicado: (2011)

Synaptotagmin-1 functions as the Ca(2+)-sensor for spontaneous release
por: Xu, Jun, et al.
Publicado: (2009)

The C2b Domain of Synaptotagmin Is a Ca(2+)–Sensing Module Essential for Exocytosis
por: Desai, Radhika C., et al.
Publicado: (2000)

Productive and Non-productive Pathways for Synaptotagmin 1 to Support Ca(2+)-Triggered Fast Exocytosis
por: Kim, Jaewook, et al.
Publicado: (2017)

Regulation of Exocytosis and Fusion Pores by Synaptotagmin-Effector Interactions
por: Zhang, Zhen, et al.
Publicado: (2010)

A molecular mechanism for calcium/synaptotagmin-triggered exocytosis
por: Kiessling, Volker, et al.
Publicado: (2018)

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release
por: Maximov, Anton, et al.
Publicado: (2007)

Effect of Calcium ion on synaptotagmin-like protein during pre-fusion of vesicle for exocytosis in blood-brain barrier
por: Van Dinh, Quyen, et al.
Publicado: (2020)

A New Role for a Synaptotagmin Protein in Calcium-Dependent Exocytosis
Publicado: (2004)

Synaptotagmin VII Restricts Fusion Pore Expansion during Lysosomal Exocytosis
por: Jaiswal, Jyoti K, et al.
Publicado: (2004)

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis
por: Ramakrishnan, Sathish, et al.
Publicado: (2020)

Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity
por: Shimojo, Masafumi, et al.
Publicado: (2019)

Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles
por: Bacaj, Taulant, et al.
Publicado: (2015)

Age-dependent Preferential Dense-Core Vesicle Exocytosis in Neuroendocrine Cells Revealed by Newly Developed Monomeric Fluorescent Timer Protein
por: Tsuboi, Takashi, et al.
Publicado: (2010)

Imaging a target of Ca(2+) signalling: Dense core granule exocytosis viewed by total internal reflection fluorescence microscopy
por: Ravier, Magalie A., et al.
Publicado: (2008)

The Exocytosis-Regulatory Protein Synaptotagmin VII Mediates Cell Invasion by Trypanosoma cruzi
por: Caler, Elisabet V., et al.
Publicado: (2001)

VAMP2 and synaptotagmin mobility in chromaffin granule membranes: implications for regulated exocytosis
por: Abbineni, Prabhodh S., et al.
Publicado: (2022)

The tandem C2 domains of synaptotagmin contain redundant Ca(2)+ binding sites that cooperate to engage t-SNAREs and trigger exocytosis
por: Earles, Cynthia A., et al.
Publicado: (2001)

Molecular mechanism of the synaptotagmin–SNARE interaction in Ca(2+)-triggered vesicle fusion
por: Vrljic, Marija, et al.
Publicado: (2010)

Synaptotagmin 7 functions as a Ca(2+)-sensor for synaptic vesicle replenishment
por: Liu, Huisheng, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_1139a2do4306g25415jktubra1