Inhibition and Redistribution of NHE3, the Apical Na(+)/H(+) Exchanger, by Clostridium difficile Toxin B

NHE3, the apical isoform of the Na(+)/H(+) exchanger, is central to the absorption of salt and water across the intestinal epithelium. We report that treatment of epithelial cells with toxin B of Clostridium difficile, a diarrheal pathogen, causes a pronounced inhibition of NHE3 activity, with littl...

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Detalles Bibliográficos
Autores principales: Hayashi, Hisayoshi, Szászi, Katalin, Coady-Osberg, Natasha, Furuya, Wendy, Bretscher, Anthony P., Orlowski, John, Grinstein, Sergio
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234495/
https://www.ncbi.nlm.nih.gov/pubmed/15078917
http://dx.doi.org/10.1085/jgp.200308979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234495/
https://www.ncbi.nlm.nih.gov/pubmed/15078917
http://dx.doi.org/10.1085/jgp.200308979

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